ABSTRACT
<p><b>OBJECTIVE</b>To determine the expression of Omi/HtrA2 in the spermatozoa of chronic bacterial prostatitis patients and explore the potential mechanism of chronic prostatitis inducing male infertility.</p><p><b>METHODS</b>Forty-one patients diagnosed as suffering from chronic prostatitis were included, and so were 12 healthy normal men as controls. Spermatozoa in the semen were purified by Percoll gradient technique to separate the seminal plasma and other round cells. Sperm concentration, motility, morphology, pro-inflammatory cytokines, Omi/HtrA2 mRNA and protein levels in the spermatozoa of the patients were measured.</p><p><b>RESULTS</b>Significantly increased levels of pro-inflammatory cytokines were observed in the seminal plasma of the prostatitis patients, and so were Omi/HtrA2 mRNA and protein levels as compared with the normal men.</p><p><b>CONCLUSION</b>Chronic prostatitis patients presented important alterations in semen quality parameters and up-regulated expression of Omi/HtrA2 mRNA and proteins in the spermatozoa.</p>
Subject(s)
Adolescent , Adult , Humans , Male , Middle Aged , Blotting, Western , Gene Expression , High-Temperature Requirement A Serine Peptidase 2 , Interleukin-1beta , Mitochondrial Proteins , Genetics , Metabolism , Prostatitis , Genetics , Metabolism , Pathology , RNA, Messenger , Genetics , Metabolism , Reverse Transcriptase Polymerase Chain Reaction , Serine Endopeptidases , Genetics , Metabolism , Sperm Count , Sperm Motility , Spermatozoa , Metabolism , Tumor Necrosis Factor-alphaABSTRACT
<p><b>OBJECTIVE</b>To study the etiopathogenesis and management of seminal vesicle enlargement.</p><p><b>METHODS</b>Forty-six cases of seminal vesicle were selected, of which 36 were vesiculitis, treated by antibiotics through a catheter indwelt in the seminal vesicle for 1 week, 3 were cystic vesicular seminalis, given anti-inflammatory treatment by catheter administration and hydatid fluid inhalation, 1 was calculus at the orifice of the ejaculatory duct, taken out by transurethral resection of the verumontanum, 1 was polypous at the orifice of the verumontanum, removed by transurethral resection, 2 were posterior urethritis, treated by fulguration, and 3 were prostatic carcinoma, treated by radical prostatectomy and spermatocystotomy.</p><p><b>RESULTS</b>Hemospermia disappeared in 32 cases of vesiculitis during the 6-24 months follow-up, 4 cases experienced recurrent hemospermia 3 months after the treatment. No recurrence was observed in any other case of cystic vesicular seminalis, calculus, polypous, posterior urethritis and prostatic carcinoma.</p><p><b>CONCLUSION</b>Seminal vesicle enlargement has intricate etiopathogenesis, but can be treated with satisfactory results if managed properly.</p>
Subject(s)
Adolescent , Adult , Humans , Male , Middle Aged , Follow-Up Studies , Genital Diseases, Male , Therapeutics , Seminal Vesicles , Pathology , Treatment OutcomeABSTRACT
Male acquired urinary incontinence can be a complication of radical prostatectomy and posterior urethroplasty. Mild urinary incontinence can be improved by pelvic floor exercises, biofeedback and medicine treatment. Severe urinary incontinence requires more active treatment, such as injection therapy, artificial urethral sphincter insertion, and bulbourethral sling. Recent progress in the treatment of male acquired urinary incontinence is reviewed in this article.